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All research overviewsRESEARCH OVERVIEW

What Is Melanotan II?

Last reviewed: 17 August 2026

Melanotan II lyophilised reference material vial

Melanotan II is a synthetic cyclic analogue of α-MSH studied as an agonist across multiple melanocortin receptor subtypes. Its cyclic lactam structure is the feature that gives it stability relative to the linear parent hormone.

Cyclic heptapeptideNon-selective MCR agonistPreclinical + limited human data
Research use only · Not for human consumption · 18+. This page describes the published scientific record for laboratory and educational research. It is not medical advice and not a recommendation to administer this compound to humans or animals.

How is Melanotan II classified?

A cyclic heptapeptide melanocortin agonist, described as non-selective because it engages MC1R, MC3R, MC4R and MC5R rather than a single subtype — the key distinction from PT-141, which is studied for central receptor activity.

How is its mechanism studied?

  • MC1R signalling in melanocyte models, studied in pigmentation research.
  • MC3R and MC4R engagement, studied in central appetite and behaviour models.
  • Receptor-binding affinity panels used to characterise selectivity.

What kind of research exists?

Receptor pharmacology from the 1990s onward, animal models, and a case-report literature describing outcomes associated with unregulated non-research use. That case literature is an important part of the published record and is one reason this compound is supplied for laboratory use only.

What is it studied alongside?

PT-141 (bremelanotide), Melanotan I (afamelanotide) and α-MSH as the reference endogenous ligand.

How does Neo Labs supply and handle it?

Lyophilised powder, third-party tested, batch COA. Cold, dark storage; laboratory use only.

Primary literature

We link live PubMed searches rather than a fixed citation list, so you always land on the current indexed record — including papers published after this page was reviewed.

The indexed literature for these compounds is predominantly preclinical. Citations are provided for scientific reference and do not imply any human-use indication.

Important

For research use only. Not for human or veterinary consumption. Neo Labs supplies this compound solely as a laboratory reference material and makes no therapeutic, medical or performance claims. Nothing on this page is medical advice.

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