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All research overviewsRESEARCH OVERVIEW

What Is KPV?

Last reviewed: 17 August 2026

KPV lyophilised reference material vial

KPV is the C-terminal tripeptide fragment (lysine-proline-valine) of α-melanocyte-stimulating hormone. Research examines it as a minimal sequence retaining some of the signalling behaviour studied in the parent hormone, without the pigmentation-related receptor activity.

Tripeptideα-MSH C-terminal fragmentPreclinical
Research use only · Not for human consumption · 18+. This page describes the published scientific record for laboratory and educational research. It is not medical advice and not a recommendation to administer this compound to humans or animals.

How is KPV classified?

A melanocortin-derived tripeptide. Because it is so short, it is often described in the literature as a 'minimal active fragment' rather than a receptor agonist in the conventional sense.

How is its mechanism studied?

  • NF-κB pathway readouts in cultured epithelial and immune cells.
  • Cytokine expression endpoints in preclinical colitis and dermal models.
  • Peptide-transporter-mediated cellular uptake, studied as a route into the cell.

What kind of research exists?

Predominantly in vitro and rodent work. Human data is very limited, so KPV findings should be read as pathway-level observations in models.

What is it studied alongside?

α-MSH and related melanocortin fragments, and in combination reference materials with BPC-157 and TB-500.

How does Neo Labs supply and handle it?

Lyophilised powder, batch COA available against the lot number. Cold, light-protected storage.

Primary literature

We link live PubMed searches rather than a fixed citation list, so you always land on the current indexed record — including papers published after this page was reviewed.

The indexed literature for these compounds is predominantly preclinical. Citations are provided for scientific reference and do not imply any human-use indication.

Important

For research use only. Not for human or veterinary consumption. Neo Labs supplies this compound solely as a laboratory reference material and makes no therapeutic, medical or performance claims. Nothing on this page is medical advice.

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