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All research overviewsRESEARCH OVERVIEW

What Is PT-141?

Last reviewed: 17 August 2026

PT-141 lyophilised reference material vial

PT-141, also known as bremelanotide, is a synthetic cyclic peptide and a metabolite-derived relative of Melanotan II. Research characterises it as acting primarily at central melanocortin receptors rather than at the pigmentation-associated MC1R.

Cyclic heptapeptideMC3R / MC4RHuman trial literature
Research use only · Not for human consumption · 18+. This page describes the published scientific record for laboratory and educational research. It is not medical advice and not a recommendation to administer this compound to humans or animals.

How is PT-141 classified?

A melanocortin receptor agonist with a receptor profile weighted toward MC3R and MC4R. This shift in selectivity relative to Melanotan II is the defining classification point in the literature.

How is its mechanism studied?

  • MC4R signalling in central nervous system models.
  • Neural pathway activation studied with imaging and behavioural endpoints in animals.
  • Receptor-binding panels used to establish subtype preference.

What kind of research exists?

Unusually for a peptide in this library, PT-141 has a published randomised-trial record in addition to receptor pharmacology and animal work — a result of its development programme.

What is it studied alongside?

Melanotan II and α-MSH, and in central-receptor reviews alongside other MC4R-targeting compounds.

How does Neo Labs supply and handle it?

Lyophilised powder, sealed vial, batch COA. Cold, dark storage.

Primary literature

We link live PubMed searches rather than a fixed citation list, so you always land on the current indexed record — including papers published after this page was reviewed.

The indexed literature for these compounds is predominantly preclinical. Citations are provided for scientific reference and do not imply any human-use indication.

Important

For research use only. Not for human or veterinary consumption. Neo Labs supplies this compound solely as a laboratory reference material and makes no therapeutic, medical or performance claims. Nothing on this page is medical advice.

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