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All research overviewsRESEARCH OVERVIEW

What Is Semax?

Last reviewed: 17 August 2026

Semax lyophilised reference material vial

Semax is a synthetic analogue of the ACTH(4-10) fragment, extended with Pro-Gly-Pro for stability. Critically for how it is classified, the fragment lacks the corticotropic activity of full-length ACTH — it is studied for neurotrophic signalling, not hormonal output.

HeptapeptideACTH(4-10) analogueNon-corticotropic
Research use only · Not for human consumption · 18+. This page describes the published scientific record for laboratory and educational research. It is not medical advice and not a recommendation to administer this compound to humans or animals.

How is Semax classified?

A non-corticotropic melanocortin-fragment analogue, grouped with Selank as part of the same short-neuropeptide research family.

How is its mechanism studied?

  • BDNF and TrkB expression in rodent hippocampal tissue.
  • Dopaminergic and serotonergic system readouts in animal models.
  • Gene-expression profiling in neuroprotection and ischaemia models.

What kind of research exists?

As with Selank, much of the primary literature originates from Russian institutions, including clinical use reports that are not represented in Western regulatory review. English-language indexing is incomplete.

What is it studied alongside?

Selank, ACTH fragments, and other neurotrophic-signalling research peptides.

How does Neo Labs supply and handle it?

Lyophilised powder, sealed vial, batch COA against the lot. Cold, dark storage.

Primary literature

We link live PubMed searches rather than a fixed citation list, so you always land on the current indexed record — including papers published after this page was reviewed.

The indexed literature for these compounds is predominantly preclinical. Citations are provided for scientific reference and do not imply any human-use indication.

Important

For research use only. Not for human or veterinary consumption. Neo Labs supplies this compound solely as a laboratory reference material and makes no therapeutic, medical or performance claims. Nothing on this page is medical advice.

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