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All research overviewsRESEARCH OVERVIEW

What Is MOTS-c?

Last reviewed: 17 August 2026

MOTS-c lyophilised reference material vial

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene — one of a small set of peptides transcribed from mitochondrial rather than nuclear DNA. It is studied as a signalling molecule linking mitochondrial state to cellular metabolism.

16-amino-acid peptideMitochondrial-derivedCell + animal models
Research use only · Not for human consumption · 18+. This page describes the published scientific record for laboratory and educational research. It is not medical advice and not a recommendation to administer this compound to humans or animals.

How is MOTS-c classified?

It belongs to the mitochondrial-derived peptide (MDP) family, alongside humanin and the SHLP series. The defining classification feature is its genomic origin, not a receptor target.

How is its mechanism studied?

  • AMPK pathway activation in cell and rodent models.
  • Folate-methionine cycle intermediates, proposed in published work as an upstream link to AMPK.
  • Nuclear translocation under metabolic stress, studied with imaging and reporter assays.

What kind of research exists?

MOTS-c research is largely cell-biology and rodent work published from 2015 onward, plus observational human studies of circulating peptide levels. Interventional human data is minimal.

What is it studied alongside?

Humanin and SHLP peptides within the MDP family, and SS-31 in broader mitochondrial-research reviews.

How does Neo Labs supply and handle it?

Lyophilised powder, HPLC-verified, batch COA. Cold, dark storage for sealed vials.

Primary literature

We link live PubMed searches rather than a fixed citation list, so you always land on the current indexed record — including papers published after this page was reviewed.

The indexed literature for these compounds is predominantly preclinical. Citations are provided for scientific reference and do not imply any human-use indication.

Important

For research use only. Not for human or veterinary consumption. Neo Labs supplies this compound solely as a laboratory reference material and makes no therapeutic, medical or performance claims. Nothing on this page is medical advice.

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